Notice how in most RPG and other games, final bosses who are bosses or the like normally seem like big cowards always getting lackeys to do the work for them when in reality they could crush the hero with a finger at the start of the game? I know it's to futhur the plot and make the game possible but it is sstill strange.

I believe your kinda wrong there. FF12, Vayne & Gabranth kill of the supose-to-be main character. Later on in the game, vayne is just too busy preparing for war to deal with Vaan & his playschool group personally.



Ever notice that most main characters from an FPS/TPS have taken some sort of body enhancement drug.

And how the bad guys in every game always throw their least experienced goons () at you first? You'd think it would make more sense to get a few experienced ones after you a first, since you'd have nearly no weapons whatsoever ><

That is of course, for nearly every game in existance

Yeap exactly, notice why they never send their most powerful assistants or lackeys to deal with you or do it themselves but send some weak monsters or what not even in games where you're considered a major threat

The Mario games are a perfect example. How many times has Bowser tried to kidnap Peach and sent the goombas after Mario, even though they wouldn't be able to capture him or even do any damage to him.